| semaglutide | thirzepatide | retatruticde |
| Mechanism of action: Semaglutide, which is an analog of GLP-1 (glucagon-like peptide-1), meaning that it mimics the action of a naturally occurring hormone in the body that helps regulate blood sugar levels. Semaglutide increases insulin secretion when blood sugar levels are high, and decreases glucagon production. | Mechanism of action: thiothiopatide is a novel drug that simultaneously mimics the action of GLP-1 and GIP (glucose-dependent insulinotropic peptide). This dual activity makes it extremely effective in controlling blood sugar levels and promoting weight loss by affecting appetite and metabolism. | Mechanism of action: Retatrutide has a “TRIPLE” effect. – on receptors GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic peptide) and on THIRD- glucagon receptor, through which also regulates lipid and glucose metabolism. |
| Applications: In addition to treating type 2 diabetes, semaglutide is used in the treatment of obesity due to its ability to reduce appetite and promote feelings of satiety. | Uses: thiothiazepatide is used to treat type 2 diabetes and, like semaglutide, has shown promise in treating obesity. | Applications: Retatrutide acts like GLP-1, GIP and a third hormone known as glucagon, which is also involved in regulating hunger. |
| In the treatment of obesity : In clinical trials, people taking higher doses of semaglutide specifically designed to treat obesity were able to lose an average of about 10-15% of their initial body weight in 68 weeks. | For the treatment of type 2 diabetes and obesity: In clinical trials, thiothiazepatide has shown promising results in reducing body weight. Participants in the study were able to lose between about 15% and 20% of their initial body weight in 72 weeks, depending on the dose and individual body responses. | In the treatment of obesity : A recent study shows that patients treated with Triple G were able to lose as much as 24.2% of their total body weight. This is the best result so far among other substances with similar effects. |