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Comparison of semaglutide, tirzepatide, retatrutide

semaglutide thirzepatide retatruticde

Mechanism of action: Semaglutide, which is an analog of GLP-1 (glucagon-like peptide-1), meaning that it mimics the action of a naturally occurring hormone in the body that helps regulate blood sugar levels. Semaglutide increases insulin secretion when blood sugar levels are high, and decreases glucagon production.

Mechanism of action: thiothiopatide is a novel drug that simultaneously mimics the action of GLP-1 and GIP (glucose-dependent insulinotropic peptide). This dual activity makes it extremely effective in controlling blood sugar levels and promoting weight loss by affecting appetite and metabolism.

Mechanism of action: Retatrutide has a “TRIPLE” effect. – on receptors GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic peptide) and on THIRD-  glucagon receptor, through which also regulates lipid and glucose metabolism.

Applications: In addition to treating type 2 diabetes, semaglutide is used in the treatment of obesity due to its ability to reduce appetite and promote feelings of satiety. 

Uses: thiothiazepatide is used to treat type 2 diabetes and, like semaglutide, has shown promise in treating obesity.

Applications: Retatrutide acts like GLP-1, GIP and a third hormone known as glucagon, which is also involved in regulating hunger.

In the treatment of obesity In clinical trials, people taking higher doses of semaglutide specifically designed to treat obesity were able to lose an average of about 10-15% of their initial body weight in 68 weeks.

For the treatment of type 2 diabetes and obesity: In clinical trials, thiothiazepatide has shown promising results in reducing body weight. Participants in the study were able to lose between about 15% and 20% of their initial body weight in 72 weeks, depending on the dose and individual body responses.

In the treatment of obesity A recent study shows that patients treated with Triple G were able to lose as much as 24.2% of their total body weight. This is the best result so far among other substances with similar effects.

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